Interleukin 19 and Interleukin 22 serum levels are decreased in ovarian endometrioma

Serum interleukin-19 and -22 are decreased in ovarian endometrioma. They may be involved in the pathogenesis of endometriosis.

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Pietro Santulli, M.D., Bruno Borghese, M.D., Ph.D., Sandrine Chouzenoux, Isabelle Streuli, M.D., Didier Borderie, M.D., Ph.D., Dominique de Ziegler, M.D., Bernard Weill, M.D., Ph.D., Charles Chapron, M.D., Frederic Batteux, M.D., Ph.D.

Volume 99, Issue 1, Pages 219-226.e2, January 2013



To determine the serum levels of IL-10 family interleukins in women with ovarian endometriosis and investigate the correlation of these levels with disease activity.


A case-control laboratory study


Tertiary-care university hospital


219 women, with (n=112) and without (n=107) endometriosis.


Complete surgical excision with pathological analysis.

Main Outcome Measure(s):

Blood samples were obtained during surgical procedures. IL-10, 19, 20, 22 were assayed by ELISA in sera, and the concentrations correlated with the extent and the severity of the disease.


IL-19 was detectable in 18.3% and IL-22 in 47.9% of sera samples from all 219 women studied. Serum IL-19 was lower in women with endometriosis (median, 292.7 pg/ml; range, 32.2 to 1339.3) than in endometriosis-free women (median, 1035.8 pg/ml; range, 32.2 to 2000.0; p=0.006). In addition, serum IL-22 levels were decreased in women affected by endometriosis (median, 352.0 pg/ml; range, 31.2 to 1392.2) as compared to endometriosis-free women (median, 709.2 pg/ml; range, 73.3 to 2012.0; p<0.001). We found significant correlations between serum IL-22 concentrations and intensity of deep dyspareunia (r=-0,303; p=0.002) and non cyclic chronic pelvic pain (r=-0,212; p=0.025). IL-19 was correlated with the intensity of deep dyspareunia (r=-0,749; p<0.001). Conclusions:

Serum IL-19 and IL-22 are decreased in women with ovarian endometrioma. IL-10 family interleukins may be involved in the pathogenesis of endometriosis.

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