Aromatase inhibitors for male infertility

Aromatase inhibitors increase serum testosterone levels and can improve sperm production for infertile men with low serum testosterone and increased testosterone/estradiol ratios.


Peter Schlegel, M.D.

Volume 98, Issue 6, Pages 1359-1362, December 2012


Men with severely defective sperm production commonly have excess aromatase activity, reflected by low serum testosterone and relatively elevated estradiol levels. Aromatase inhibitors can increase endogenous testosterone production and serum testosterone levels. Treatment of infertile males with the aromatase inhibitors testolactone, anastrazole and letrozole has been associated with increased sperm production and return of sperm to the ejaculate in men with non-obstructive azoospermia. Randomized controlled trials are needed to define the magnitude of benefit of aromatase inhibitor treatment for infertile men.

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