A historical perspective of aromatase inhibitors for ovulation induction

This review provides a brief history of the development of letrozole for ovulation induction.

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Robert F. Casper, M.D. and Mohamed F. M. Mitwally, M.D., H.C.L.D.

Volume 98, Issue 6, Pages 1352-1355, December 2012


The concept of using aromatase inhibitors in place of clomiphene citrate (CC) for ovulation induction was introduced more than 10 years ago and a brief history of its development is presented. Worldwide usage for ovulation induction, and as an adjunct for intrauterine insemination and in vitro fertilization has occurred despite the absence of definitive data of superiority to CC. The results of two ongoing potentially definitive multicenter trials of efficacy and safety of letrozole compared to CC are eagerly awaited.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)02308-4/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.