Authors

Ellen W. Freeman, Ph.D., Mary D. Sammel, Sc.D., Hui Lin, M.S., David W. Boorman, M.S., Clarisa R. Gracia, M.D.

Vol 98, Issue 5, Pages 1254-1259.e2

Abstract

Objective:

To determine the rate of change of antimullerian hormone (AMH) in the late reproductive years and its associations with time to menopause (TTM). We hypothesized that the rate of change between 2 measures of AMH reflects follicular atresia and varies among women independent of age.

Design:

A 14-year follow-up.

Setting:

A randomly identified, population-based cohort (Penn Ovarian Aging Study).

Subjects:

Two measures of AMH were evaluated in survival analysis of 293 women.

Intervention:

None.

Main Outcome Measure:

Time to menopause.

Results:

The rate of AMH change was a strong independent predictor of TTM in multivariable analysis after adjusting for AMH baseline, age and smoking (hazard ratio for 1 SD change = 1.82, 95% CI: 1.56 – 2.14, P

Conclusions:

AMH rate of change was independently associated with TTM in late reproductive-age women and increased the precision of estimates of TTM when included with an AMH baseline level and age. The rate of AMH change may be a more direct surrogate than age and increases the precision of estimates of TTM during this clinically important time period.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)01892-4/fulltext