Safety of uterine and or ovarian preservation in young women with grade 1 intramucous endometrial adenocarcinoma A comparison of survival according to the extent of surgery

Analyzing 489 patients who were 40 years of age or younger with grade 1 intramucous endometrial adenocarcinoma, uterine and ovarian preservation was not associated with an increase in cancer-related mortality.

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Authors

Martin Koskas, M.D., Sofiane Bendifallah, M.D., Dominique Luton, M.D., Ph.D., Emile Daraï, M.D., Ph.D., Roman Rouzier, M.D., Ph.D.

Vol 98, Issue 5, Pages 1229-1235

Abstract

Objective:

To compare the survival of patients with grade 1 intramucous endometrial adenocarcinoma according to the extent of surgery.

Design:

Retrospective cohort study.

Setting:

Not applicable.

Patient(s):

A cohort of 489 patients who were 40 years of age or younger with grade 1 intramucous endometrial adenocarcinoma.

Intervention(s):

The patients were divided into the following three groups: 101 patients who underwent uterine preservation, 184 patients who underwent ovarian preservation, and 204 patients who underwent hysterectomy with oophorectomy.

Main Outcome Measures:

The demographics and survival rates were compared.

Result(s):

In the multivariate analysis, no factors were associated with ovarian preservation. In the multivariate analysis, the factors that were associated with uterine preservation were a later year of diagnosis (p<0.001) and young age (p<0.001). In a multivariate Cox model, ovarian and uterine preservation had no effect on either cancer-specific or overall survival. Conclusion(s):

In patients with grade 1 intramucous endometrial adenocarcinoma, uterine and ovarian preservation were not associated with an increase in cancer-related mortality. Longer follow up is needed to confirm the safety of a conservative approach toward the ovaries and/or the uterus.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)01950-4/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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