Safety of uterine and or ovarian preservation in young women with grade 1 intramucous endometrial adenocarcinoma A comparison of survival according to the extent of surgery

Analyzing 489 patients who were 40 years of age or younger with grade 1 intramucous endometrial adenocarcinoma, uterine and ovarian preservation was not associated with an increase in cancer-related mortality.

Like Comment

Authors

Martin Koskas, M.D., Sofiane Bendifallah, M.D., Dominique Luton, M.D., Ph.D., Emile Daraï, M.D., Ph.D., Roman Rouzier, M.D., Ph.D.

Vol 98, Issue 5, Pages 1229-1235

Abstract

Objective:

To compare the survival of patients with grade 1 intramucous endometrial adenocarcinoma according to the extent of surgery.

Design:

Retrospective cohort study.

Setting:

Not applicable.

Patient(s):

A cohort of 489 patients who were 40 years of age or younger with grade 1 intramucous endometrial adenocarcinoma.

Intervention(s):

The patients were divided into the following three groups: 101 patients who underwent uterine preservation, 184 patients who underwent ovarian preservation, and 204 patients who underwent hysterectomy with oophorectomy.

Main Outcome Measures:

The demographics and survival rates were compared.

Result(s):

In the multivariate analysis, no factors were associated with ovarian preservation. In the multivariate analysis, the factors that were associated with uterine preservation were a later year of diagnosis (p<0.001) and young age (p<0.001). In a multivariate Cox model, ovarian and uterine preservation had no effect on either cancer-specific or overall survival. Conclusion(s):

In patients with grade 1 intramucous endometrial adenocarcinoma, uterine and ovarian preservation were not associated with an increase in cancer-related mortality. Longer follow up is needed to confirm the safety of a conservative approach toward the ovaries and/or the uterus.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)01950-4/fulltext


Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.