Interpreting human follicular recruitment and antimullerian hormone concentrations throughout life

The relationships between primordial follicles, follicular recruitment, and circulating AMH are dynamic, reflecting the different stages of the reproductive lifespan. This article discusses these relationships and their clinical implications.

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Authors

Richard Fleming, Ph.D., Thomas W. Kelsey, Ph.D., Richard A. Anderson, M.D., Ph.D., W. Hamish Wallace, M.D., Scott M. Nelson, Ph.D.

Vol 98, Issue 5, Pages 1097-1102

Abstract

The changes in the relationships between circulating anti-Mullerian hormone (AMH), the size of the primordial follicle pool and follicular recruitment before and through the reproductive years have now been clarified, and show dynamic changes through sexual development. The constant relationship between the number of follicles and circulating AMH exists only after the age of 25 years, implying that the association between follicular recruitment and follicular survival to the later stages of development is not constant across the reproductive lifecourse. This commentary assesses the factors which may underlie these relationships and their clinical implications for reproductive health.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)01850-X/fulltext


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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