Ectopic pregnancy How the diagnostic and therapeutic management has changed

The diagnosis and treatment of ectopic pregnancy has changed drastically over the last century. A comprehensive overview of the historical developments leading to current clinical practice was attempted.

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Norah Melina van Mello, M.D., Femke Mol, M.D., Willem M. Ankum, M.D., Ph.D., Ben Willem Mol, M.D., Ph.D., Fulco van der Veen, M.D., Ph.D., Petra J. Hajenius, M.D., Ph.D.

Vol 98, Issue 5, Pages 1066-1073


Nowadays ectopic pregnancy often can be diagnosed before the woman's condition has deteriorated, which has altered the former clinical picture of a life-threatening disease into a more benign condition. This review describes the historical developments in the diagnostic and therapeutic management of ectopic pregnancy leading up to current clinical practice. The first attempts to diagnose ectopic pregnancy originate from the beginning of the 20th century.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.