Does the level of serum antimullerian hormone predict ovulatory function in women with Polycystic Ovary Syndrome with aging
Anovulatory women with polycystic ovary syndrome (PCOS) and matched control subjects were followed for 5 years. Women with PCOS who had normal menses after 5 years had significantly lower initial serum antimullerian hormone levels.
Authors
Enrico Carmina, M.D., Anna Maria Campagna, M.D., Pasquale Mansuet, M.D., Giustina Vitale, M.D., Daniel Kort, M.D., Roger Lobo, M.D.
Vol 98, Issue 4, Pages 1043-1046
Abstract
Objective:
To determine possible prediction of regular menses with aging in anovulatory women with PCOS.
Design:
Cohort.
Setting:
Academic practice.
Patients:
A total of 54 anovulatory women with PCOS and 28 age- and weight-matched controls.
Interventions:
Blood and ovarian ultrasound at baseline and after 5 years.
Major Outcome Measures:
Serum AMH, gonadotropins, androgens, insulin sensitivity, AMH, and ovarian ultrasound.
Results:
After 5 years, there was a significant decrease in AMH in women with PCOS and controls. (Ten of 54 anovulatory women became ovulatory after 5 yrs.) There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH (< 4ng/ml) was associated with ovulatory function. Conclusion:
Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS.
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