Enrico Carmina, M.D., Anna Maria Campagna, M.D., Pasquale Mansuet, M.D., Giustina Vitale, M.D., Daniel Kort, M.D., Roger Lobo, M.D.
Vol 98, Issue 4, Pages 1043-1046
To determine possible prediction of regular menses with aging in anovulatory women with PCOS.
A total of 54 anovulatory women with PCOS and 28 age- and weight-matched controls.
Blood and ovarian ultrasound at baseline and after 5 years.
Major Outcome Measures:
Serum AMH, gonadotropins, androgens, insulin sensitivity, AMH, and ovarian ultrasound.
After 5 years, there was a significant decrease in AMH in women with PCOS and controls. (Ten of 54 anovulatory women became ovulatory after 5 yrs.) There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH (< 4ng/ml) was associated with ovulatory function. Conclusion:
Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS.
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