Does the level of serum antimullerian hormone predict ovulatory function in women with Polycystic Ovary Syndrome with aging

Anovulatory women with polycystic ovary syndrome (PCOS) and matched control subjects were followed for 5 years. Women with PCOS who had normal menses after 5 years had significantly lower initial serum antimullerian hormone levels.


Enrico Carmina, M.D., Anna Maria Campagna, M.D., Pasquale Mansuet, M.D., Giustina Vitale, M.D., Daniel Kort, M.D., Roger Lobo, M.D.

Vol 98, Issue 4, Pages 1043-1046



To determine possible prediction of regular menses with aging in anovulatory women with PCOS.




Academic practice.


A total of 54 anovulatory women with PCOS and 28 age- and weight-matched controls.


Blood and ovarian ultrasound at baseline and after 5 years.

Major Outcome Measures:

Serum AMH, gonadotropins, androgens, insulin sensitivity, AMH, and ovarian ultrasound.


After 5 years, there was a significant decrease in AMH in women with PCOS and controls. (Ten of 54 anovulatory women became ovulatory after 5 yrs.) There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH (< 4ng/ml) was associated with ovulatory function. Conclusion:

Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS.

Read the full text at:

Please sign in or register for FREE

Your Fertility and Sterility Dialog login information is not the same as your ASRM or EES credentials. Users must create a separate account to comment or interact on the Dialog.