Early progesterone cessation after in vitro fertilization intracytoplasmic sperm injection A randomized, controlled trial

Luteal phase supplementation with vaginal progesterone after in vitro fertilization/intracytoplasmic sperm injection can be safely withdrawn at 5 weeks' gestation.


Graciela Kohls, M.D., Francisco Ruiz, M.D., María Martínez, M.D., Erik Hauzman, M.D., Gabriel de la Fuente, M.D., Antonio Pellicer, M.D., Juan A Garcia-Velasco, M.D.

Vol 98, Issue 4, Pages 858-862



To investigate the effect of stopping progesterone (P) support at week 5 versus week 8 on ongoing pregnancy rate after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).


Prospective, randomized, controlled trial.


University-affiliated infertility center.


A total of 220 patients with intrauterine pregnancy demonstrated by transvaginal ultrasound after IVF/ICSI.


Luteal phase support with micronized vaginal progesterone was suspended at week 5 or ar week 8.

Main Outcome Measures:

Ongoing pregnancy rate, miscarriage rate, and number of bleeding episodes.


Progesterone levels were similar on the day of the first pregnancy ultrasound exam (149 ± 108 vs. 167 ± 115 ng/mL). Significantly more bleeding episodes were observed in the first trimester in the group with early cessation of P supplementation (18.0 ± 2.6 vs. 7.2 ± 1.3 episodes). Miscarriage rates among singleton pregnancies were similar in the two groups (5/80 vs. 6/79).


Vaginal P supplementation after IVF/ICSI can be safely withdrawn at 5 weeks' gestation, because cycle outcome was similar to conventional luteal phase support up to 8 weeks of pregnancy.

Clinical Trial Registration Number:


Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00600-0/fulltext