Early progesterone cessation after in vitro fertilization intracytoplasmic sperm injection A randomized, controlled trial

Luteal phase supplementation with vaginal progesterone after in vitro fertilization/intracytoplasmic sperm injection can be safely withdrawn at 5 weeks' gestation.

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Graciela Kohls, M.D., Francisco Ruiz, M.D., María Martínez, M.D., Erik Hauzman, M.D., Gabriel de la Fuente, M.D., Antonio Pellicer, M.D., Juan A Garcia-Velasco, M.D.

Vol 98, Issue 4, Pages 858-862



To investigate the effect of stopping progesterone (P) support at week 5 versus week 8 on ongoing pregnancy rate after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).


Prospective, randomized, controlled trial.


University-affiliated infertility center.


A total of 220 patients with intrauterine pregnancy demonstrated by transvaginal ultrasound after IVF/ICSI.


Luteal phase support with micronized vaginal progesterone was suspended at week 5 or ar week 8.

Main Outcome Measures:

Ongoing pregnancy rate, miscarriage rate, and number of bleeding episodes.


Progesterone levels were similar on the day of the first pregnancy ultrasound exam (149 ± 108 vs. 167 ± 115 ng/mL). Significantly more bleeding episodes were observed in the first trimester in the group with early cessation of P supplementation (18.0 ± 2.6 vs. 7.2 ± 1.3 episodes). Miscarriage rates among singleton pregnancies were similar in the two groups (5/80 vs. 6/79).


Vaginal P supplementation after IVF/ICSI can be safely withdrawn at 5 weeks' gestation, because cycle outcome was similar to conventional luteal phase support up to 8 weeks of pregnancy.

Clinical Trial Registration Number:


Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00600-0/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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