Comparison of two ready-to-use systems designed for sperm-hyaluronic acid binding selection before intracytoplasmic sperm injection: PICSI versus Sperm Slow: a prospective, randomized trial

PICSI and Sperm Slow allow comparable clinical efficiency in selecting HA-bound spermatozoa.


Lodovico Parmegiani, M.Sc., Graciela Estela Cognigni, M.D., Silvia Bernardi, B.Sc, Enzo Troilo, B.Sc., Stefania Taraborrelli, M.D., Alessandra Arnone, B.Sc., Antonio Manuel Maccarini, B.Sc., Marco Filicori, M.D.

Vol 98, Issue 3, Pages 632-637



To compare in a strict randomized way the efficiency of two ready-to-use systems for hyaluronic acid (HA)-ICSI: an HA culture dish (PICSI Sperm Selection Device), and a viscous medium containing HA (Sperm Slow).


Prospective, randomized study


GynePro Medical Centers, Bologna, Italy


50 subjects per treatment group (100 total)


100 ICSI treatments randomly carried out with PICSI or with Sperm Slow for sperm selection. Randomization conducted with sealed envelopes. ICSI performed by a single embryologist with 5-year experience in HA-ICSI.

Mean outcome measure(s):

Primary outcome measure: good-quality embryo rate.

Secondary outcome measures:

Oocyte fertilization, pregnancy and implantation rate, and the duration of the ICSI procedure.


Good quality embryo rate comparable between the two groups (58,5% PICSI® versus 56% Sperm Slow™ – P=0.691). Overall, no statistically significant differences in secondary outcome measures except ICSI procedure duration, which was 3 minutes longer (P≤0.001) in the PICSI® group.


Both PICSI® and Sperm Slow™ allow comparable clinical efficiency in selecting HA-bound spermatozoa.

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