Developmental capacity of in vitro–matured human oocytes retrieved from polycystic ovary syndrome ovaries containing no follicles larger than 6 mm

Contrary to earlier belief, immature oocytes retrieved from small antral follicles with a diameter of


Luis Guzman, M.Sc., Carolina Ortega-Hrepich, M.D., Firas K. Albuz, Ph.D., Greta Verheyen, Ph.D., Paul Devroey, M.D., Ph.D., Johan Smitz, M.D., Ph.D., Michel De Vos, M.D., Ph.D.

Vol 98, Issue 2 , Pages 503-507.e2



To test the developmental competence of oocytes in a nonhCG-triggered in vitro maturation (IVM) system when oocyte-cumulus complexes (OCC) are retrieved from antral follicles with a diameter of


Prospective cohort study.


Tertiary university-based referral center.


From January 2010 to September 2011, 121 patients with polycystic ovaries/polycystic ovary syndrome underwent 239 IVM cycles in total. In 58 of these cycles (44 patients), all antral follicles had a diameter of


NonhCG-triggered IVM of oocytes, fresh or vitrified/warmed embryo transfer (ET).

Main Outcome Measure(s):

Oocyte diameter, maturation rate, fertilization rate, embryo development and morphology, implantation rate, clinical pregnancy rate, ongoing pregnancy rate.


Oocyte retrieval yielded 16.7 OCC/cycle, and 50.8% of oocytes completed IVM. The mean oocyte diameter increased from 108.8 ± 4.3 μm to 111.9 ± 4.1 μm after IVM. Mean fertilization rate was 63.7%, and 45.4% of 2-pronuclei oocytes developed into a morphologically good-quality embryo on day 3 after intracytoplasmic sperm injection. Fresh ET resulted in two ongoing pregnancies (2/37; 5.4%). Deferred vitrified-warmed ET led to an ongoing pregnancy rate of 34.6% (9/24). Three healthy babies were born and eight pregnancies were still ongoing.


Oocytes retrieved from follicles with a diameter of

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