Expression of Phosphoinositide-specific Phospholipase C enzymes in normal endometrium and in endometriosis

The different expression of PI-PLC enzymes in the endometrium and endometriosis tissue suggests the hypothesis that PI-PLC enzymes, main effectors in PI signaling, might be involved in the pathogenesis of endometriosis.


Vincenza Rita Lo Vasco, M.D., Ph.D., Martina Leopizzi, Ph.D., Caterina Chiappetta, Ph.D., Rita Businaro, M.D., Ph.D., Patrizia Polonia, M.D., Carlo Della Rocca, M.D., Ph.D., Pietro Litta, M.D.

Vol 98, Issue 2 , Pages 410-414



To delineate the panel of expression of phosphoinositide-specific phospholipase C (PI-PLC) signaling enzymes in normal endometrium and in endometriosis.


Clinical/experimental study.




Healthy donor woman and endometriosis-affected woman.


Normal endometrium and endometriosis surgical biopsies were analyzed using gene expression analyses methodology (reverse transcriptase-polymerase chain reaction [PCR], bioanalyses).

Main Outcome Measure(s):

Gene expression (messenger RNA concentration) measures of 12 PI-PLC enzymes: PI-PLC β1, PI-PLC β2, PI-PLC β3, PI-PLC β4, PI-PLC γ1, PI-PLC γ2, PI-PLC δ1, PI-PLC δ3, PI-PLC δ4, PI-PLC ε, PI-PLC η1, and PI-PLC η2.


PI-PLC β1, PI-PLC β3, PI-PLC δ1, and PI-PLC δ3 enzymes were detected, although differently expressed in normal and endometriosis tissues.


The involvement of PI-PLC enzymes in inflammation and the consistency of susceptible endometriosis loci with PI-PLC genes mapping corroborate the hypothesis that PI signaling might be involved in the pathogenesis of endometriosis.

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