Li Wei, Ph.D., Thomas MacDonald, M.D., Sami Shimi, M.D.
Vol 98, Issue 2 , Pages 401-405
To study whether subsequent pregnancy rate is reduced after appendicectomy.
A cohort study was carried out in the General Practice Research Database, a United Kingdom primary care database.
Female patients who underwent appendicectomy between 1986 and 2009 and appropriate comparators were followed until first pregnancy.
Main Outcome Measure(s):
The association between appendicectomy and subsequent pregnancy was determined by Cox regression models.
The analyses included 76,426 appendicectomy patients, with 152,852 comparators from the database. There were 30,030 pregnancies (39.3%) in the appendicectomy cohort and 43,321 (28.3%) in the comparator cohort during a mean (SD) follow-up of 10.5 (6.6) years. Adjusted hazard ratios for subsequent birth rates were 1.54 (95% confidence interval, 1.52–1.56).
Appendicectomy was associated with increased subsequent pregnancy rate in this study. This suggests that a history of appendicectomy is not associated with impaired fertility.
Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00570-5/fulltext