Association between appendicectomy in females and subsequent pregnancy rate: A cohort study

This was a large cohort study to determine the association between appendicectomy and subsequent pregnancy rate in females. Appendicectomy was associated with increased subsequent pregnancy rates.

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Li Wei, Ph.D., Thomas MacDonald, M.D., Sami Shimi, M.D.

Vol 98, Issue 2 , Pages 401-405



To study whether subsequent pregnancy rate is reduced after appendicectomy.


A cohort study was carried out in the General Practice Research Database, a United Kingdom primary care database.


University hospital.


Female patients who underwent appendicectomy between 1986 and 2009 and appropriate comparators were followed until first pregnancy.



Main Outcome Measure(s):

The association between appendicectomy and subsequent pregnancy was determined by Cox regression models.


The analyses included 76,426 appendicectomy patients, with 152,852 comparators from the database. There were 30,030 pregnancies (39.3%) in the appendicectomy cohort and 43,321 (28.3%) in the comparator cohort during a mean (SD) follow-up of 10.5 (6.6) years. Adjusted hazard ratios for subsequent birth rates were 1.54 (95% confidence interval, 1.52–1.56).


Appendicectomy was associated with increased subsequent pregnancy rate in this study. This suggests that a history of appendicectomy is not associated with impaired fertility.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.