Renato Polimanti, Ph.D., Sara Piacentini, Ph.D., Natalia Lazzarin, M.D., Ph.D., Elena Vaquero, M.D., Maria Antonietta Re, Ph.D., Dario Manfellotto, M.D., Maria Fuciarelli, Ph.D.
Vol 98, Issue 2 , Pages 396-400
To investigate the role of glutathione S-transferases (GSTs) in the pathogenesis of recurrent miscarriage (RM).
Genetic association study.
University of Rome, Tor Vergata and San Giovanni Calibita, Fatebenefratelli Hospital.
One hundred twenty-one women with RM and 113 women without pregnancy complications.
Genomic DNA extracted from buccal cells and screening of positive/null genotypes of GSTM1 and GSTT1 genes and single nucleotide polymorphisms of GSTA1, GSTO2, and GSTP1 genes.
Main Outcome Measure(s):
Occurrence of GST polymorphisms.
Women with at least one GSTA1*-69T allele are more frequent in the RM group than in the control group: 67% vs. 48%, respectively. Significant outcomes were obtained considering different genetic models: codominant, dominant, and log-additive. In addition, the combined analysis suggests that GSTA1 and GSTM1 variants have a significant interaction in RM risk.
Our study highlighted a significant association between the GSTA1 gene and an increased risk of RM. In particular, the -69T allele in the GSTA1 gene may be considered as a predisposing factor of RM.
Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00539-0/fulltext