Authors

Robert Ochsenkühn, M.D., Andrea Arzberger, M.D., Viktoria von Schönfeldt, Ph.D., Julia Gallwas, M.D., Nina Rogenhofer, M.D., Alexander Crispin, M.D., Christian J. Thaler, M.D., Ulrich Noss, M.D.

Vol 98, Issue 2 , Pages 347-354

Abstract

Objective:

To evaluate the association between serum P levels on the day of hCG administration and pregnancy outcome in women undergoing controlled ovarian hyperstimulation, prevention of premature ovulation by GnRH analogues, and fresh ET after 5 days of embryo culture.

Design:

Retrospective, observational, cohort study.

Setting:

Private IVF center.

Patient(s):

A total of 2,555 women undergoing fresh ET on day 5 in 2,062 GnRH agonist and 493 GnRH antagonist cycles.

Intervention(s):

None.

Main Outcome Measure(s):

Live birth rate.

Result(s):

Live birth rate in cycles with GnRH agonists was significantly lower in women with P levels ≥2.0 ng/mL (17.4%) on the day of hCG administration as compared with women with P levels

Conclusion(s):

A rise of serum P levels ≥2.0 ng/mL on the day of hCG administration is associated with impaired early embryo implantation and reduced live birth rate in cycles with GnRH agonists after day-5 fresh ET.

Clinical Trial Registration Number:

NCT01426152.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00496-7/fulltext