Retrieving oocytes from small non-stimulated follicles in polycystic ovary syndrome(PCOS): in vitro maturation (IVM) is not indicated in the new GnRH antagonist era

By effectively preventing OHSS, the antagonist protocol with GnRH-a trigger is a better option for treating women with PCOS than in vitro maturation (IVM).


Dominique de Ziegler, M.D.; Isabelle Streuli, M.D.; Vanessa Gayet, M.D.; Nelly Frydman, M.D.; Osama Bajouh, M.D.; Charles Chapron, M.D.

Vol 98, Issue 2, Pages 290-293


It has been two decades since pregnancies have been obtained through in vitro maturation (IVM) of germinal vesicle-stage oocytes retrieved from nonstimulated ovaries. This technique first offered in PCOS cannot be recommended today in this indication because: (1) the results do not match those of regular ART and; (2) new GnRH antagonist and agonist-trigger protocols allow to reliably prevent OHSS.

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