Retrieving oocytes from small non-stimulated follicles in polycystic ovary syndrome(PCOS): in vitro maturation (IVM) is not indicated in the new GnRH antagonist era

By effectively preventing OHSS, the antagonist protocol with GnRH-a trigger is a better option for treating women with PCOS than in vitro maturation (IVM).

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Dominique de Ziegler, M.D.; Isabelle Streuli, M.D.; Vanessa Gayet, M.D.; Nelly Frydman, M.D.; Osama Bajouh, M.D.; Charles Chapron, M.D.

Vol 98, Issue 2, Pages 290-293


It has been two decades since pregnancies have been obtained through in vitro maturation (IVM) of germinal vesicle-stage oocytes retrieved from nonstimulated ovaries. This technique first offered in PCOS cannot be recommended today in this indication because: (1) the results do not match those of regular ART and; (2) new GnRH antagonist and agonist-trigger protocols allow to reliably prevent OHSS.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.