Spermatogonial stem cell preservation in Klinefelter boys: to bank or not to bank, that's the question

To date, retrieval of spermatogonial cells in prepubertal boys with Klinefelter syndrome should be viewed as experimental and patients and their parents must be counseled accordingly.

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Inge Gies, M.D., Jean De Schepper, M.D., Ph.D., Ellen Goossens, Ph.D., Dorien Van Saen, M.Sc., Guido Pennings, Ph.D., Herman Tournaye, M.D., Ph.D.

Vol 98, Issue 2, Pages 284-289


Although early development of testis appears normal in boys with Klinefelter syndrome (KS), spermatogonial stem cell (SSC) depletion occurs in mid puberty, leading to infertility. Therefore, freezing of semen samples or testicular tissue sampling could be offered to KS boys at onset of puberty. However, only in about half of KS patients, adult or prepubertal, spermatozoa or SSCs can be observed, and to date, no clinical parameters are available to detect patients who might benefit from these techniques. Furthermore, strategies for the further use of the cryopreserved material are still under investigation. Retrieval of spermatogonial cells in prepubertal KS boys should therefore still be viewed as experimental and patients and their parents must be counseled accordingly.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00455-4/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.