Management of a cervical heterotopic pregnancy presenting with first-trimester bleeding: case report and review of the literature

We present a case of cervical heterotopic pregnancy that was managed successfully, and we review the existing literature on this topic.


Vasiliki A. Moragianni, Benjamin D. Hamar, Colin McArdle, David A. Ryley

Vol 98, Issue 1 , Pages 89-94



To report a rare case of a cervical heterotopic pregnancy resulting from intrauterine insemination (IUI) that presented with first-trimester bleeding.


Case report and literature review.


Large university-affiliated infertility practice.


A 40-year-old gravida 2 para 1 Asian woman at 7-3/7 weeks gestational age following clomiphene citrate/IUI for the treatment of secondary infertility presented with heavy vaginal bleeding for several days.


Transvaginal ultrasound on admission revealed a single live intrauterine pregnancy and a cervical gestational sac containing a nonviable embryo. The patient continued to have vaginal bleeding and 2 days later underwent removal of the cervical ectopic pregnancy tissue with ring forceps, as well as an ultrasound-guided intracervical Foley balloon and cerclage placement. The bleeding subsided, and 48 hours later the Foley and cerclage were removed.

Main Outcome Measure(s):

Pregnancy outcome.


The remainder of the pregnancy was uncomplicated and the patient had a full-term cesarean delivery for footling breech of a healthy male infant.


Cervical heterotopic pregnancy is a very rare event that almost universally results from infertility treatment. We present a case where we were able to remove the cervical ectopic and tamponade the bleeding, thus preserving the intrauterine pregnancy for this subfertile couple, and we review the existing literature.

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