Inflammation: a link between endometriosis and preterm birth

Inflammatory events are involved in the pathogenesis of endometriosis and preterm birth, and a clinical correlation is suggested.

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Felice Petraglia, M.D., Felice Arcuri, Ph.D., Dominique de Ziegler, M.D., Charles Chapron, M.D.

Vol 98, Issue 1 , Pages 36-40


Endometriosis is a chronic inflammatory disease affecting women's health. Pain and infertility are the major symptoms caused by a hormonal/immunological dysfunction, which causes an endometrial impairment. The same pathogenetic mechanisms are also associated with preterm birth: hormones, cytokines, neurohormones, and growth factors interact in modulating extracellular matrix and prostaglandin secretion, thus activating the inflammatory process in placental membranes and myometrium. An overlap of molecules and mechanisms may explain the evidence that preterm birth is a common outcome in pregnant patients with endometriosis.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.