Endometrial reconstruction from stem cells

Adult stem cells have been identified in human endometrium. Their ability to reconstruct endometrial tissue when transplanted into immunocompromised animals suggests their potential use for treating disorders associated with inadequate endometrium.

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Authors

Caroline E. Gargett, Ph.D. and Louie Ye, Ph.D.

Vol 98, Issue 1 , Pages 11-20

Abstract

Adult stem cells have been identified in the highly regenerative human endometrium on the basis of their functional attributes. They can reconstruct endometrial tissue in vivo suggesting their possible use in treating disorders associated with inadequate endometrium. The identification of specific markers for endometrial mesenchymal stem cells and candidate markers for epithelial progenitor cells enables the potential use of endometrial stem/progenitor cells in reconstructing endometrial tissue in Asherman syndrome and intrauterine adhesions.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00541-9/fulltext


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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