Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis

Children conceived by IVF and/or ICSI are at significantly increased risk for birth defects, and there is no risk difference between IVF children and ICSI children.

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Authors

Juan Wen, B.S., Jie Jiang, B.S., Chenyue Ding, B.S., Juncheng Dai, M.D., Yao Liu, B.S., Yankai Xia, M.D., Ph.D., Jiayin Liu, M.D., Ph.D., Zhibin Hu, M.D., Ph.D.

Vol 97, Issue 6 , Pages 1331-1337.e4

Abstract

Objective:

To conduct a meta-analysis of studies assessing the effect of IVF and intracytoplasmic sperm injection (ICSI) on birth defects.

Design:

Meta-analysis.

Setting:

Centers for reproductive care.

Patient(s):

Patients treated by IVF and/or ICSI.

Intervention(s):

We identified all studies published by September 2011 with data related to birth defects in children conceived by IVF and/or ICSI compared with spontaneously conceived children, or birth defects in the children conceived by IVF compared with those by ICSI. Risk ratios from individual studies were pooled with the fixed and random effect models.

Main Outcome Measure(s):

Risk of birth defects in children conceived by IVF and/or ICSI.

Result(s):

Of 925 studies reviewed for eligibility, 802 were excluded after screening titles and abstracts, 67 were excluded for duplicated data, data unavailable, or inappropriate control group, 56 were included in the final analysis. Among the 56 studies, 46 studies had data on birth defects in children conceived by IVF and/or ICSI (124,468) compared with spontaneously conceived children. These studies provided a pooled risk estimation of 1.37 (95% confidence interval [CI]: 1.26–1.48), which is also evident in subgroup analysis. In addition, 24 studies had data on birth defects in children conceived by IVF (46,890) compared with those by ICSI (27,754), which provided an overall no risk difference.

Conclusion(s):

Children conceived by IVF and/or ICSI are at significantly increased risk for birth defects, and there is no risk difference between children conceived by IVF and/or ICSI.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00287-7/fulltext


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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