Dual trigger of oocyte maturation with gonadotropin-releasing hormone agonist and low-dose human chorionic gonadotropin to optimize live birth rates in high responders

Dual trigger with GnRH agonist and low-dose hCG in high responders with peak E2 levels

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Daniel Griffin, M.D., Claudio Benadiva, M.D., Nicole Kummer, M.D., Tara Budinetz, D.O., John Nulsen, M.D., Lawrence Engmann, M.D.

Vol 97, Issue 6 , Pages 1316-1320



To compare live birth rates after dual trigger of oocyte maturation with GnRH agonist (GnRHa) and low-dose hCG versus GnRHa alone in high responders with peak E2


Retrospective cohort study.


University-based tertiary-care fertility center.




GnRHa alone versus dual trigger.

Main Outcome Measure(s):

Live birth, implantation, and clinical pregnancy rates and OHSS.


The dual-trigger group had a significantly higher live birth rate (52.9% vs. 30.9%), implantation rate (41.9% vs. 22.1%), and clinical pregnancy rate (58.8% vs. 36.8%) compared with the GnRHa trigger group. One case of mild OHSS occurred in the dual-trigger group, and there were no cases of OHSS in the GnRHa trigger group.


Dual trigger of oocyte maturation with GnRHa and low-dose hCG in high responders with peak E2

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00329-9/fulltext

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.