Authors

Daniel Griffin, M.D., Claudio Benadiva, M.D., Nicole Kummer, M.D., Tara Budinetz, D.O., John Nulsen, M.D., Lawrence Engmann, M.D.

Vol 97, Issue 6 , Pages 1316-1320

Abstract

Objective:

To compare live birth rates after dual trigger of oocyte maturation with GnRH agonist (GnRHa) and low-dose hCG versus GnRHa alone in high responders with peak E2

Design:

Retrospective cohort study.

Setting:

University-based tertiary-care fertility center.

Patient(s):

Patients

Intervention(s):

GnRHa alone versus dual trigger.

Main Outcome Measure(s):

Live birth, implantation, and clinical pregnancy rates and OHSS.

Result(s):

The dual-trigger group had a significantly higher live birth rate (52.9% vs. 30.9%), implantation rate (41.9% vs. 22.1%), and clinical pregnancy rate (58.8% vs. 36.8%) compared with the GnRHa trigger group. One case of mild OHSS occurred in the dual-trigger group, and there were no cases of OHSS in the GnRHa trigger group.

Conclusion(s):

Dual trigger of oocyte maturation with GnRHa and low-dose hCG in high responders with peak E2

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00329-9/fulltext