Dual trigger of oocyte maturation with gonadotropin-releasing hormone agonist and low-dose human chorionic gonadotropin to optimize live birth rates in high responders
Dual trigger with GnRH agonist and low-dose hCG in high responders with peak E2 levels
Authors
Daniel Griffin, M.D., Claudio Benadiva, M.D., Nicole Kummer, M.D., Tara Budinetz, D.O., John Nulsen, M.D., Lawrence Engmann, M.D.
Vol 97, Issue 6 , Pages 1316-1320
Abstract
Objective:
To compare live birth rates after dual trigger of oocyte maturation with GnRH agonist (GnRHa) and low-dose hCG versus GnRHa alone in high responders with peak E2
Design:
Retrospective cohort study.
Setting:
University-based tertiary-care fertility center.
Patient(s):
Patients
Intervention(s):
GnRHa alone versus dual trigger.
Main Outcome Measure(s):
Live birth, implantation, and clinical pregnancy rates and OHSS.
Result(s):
The dual-trigger group had a significantly higher live birth rate (52.9% vs. 30.9%), implantation rate (41.9% vs. 22.1%), and clinical pregnancy rate (58.8% vs. 36.8%) compared with the GnRHa trigger group. One case of mild OHSS occurred in the dual-trigger group, and there were no cases of OHSS in the GnRHa trigger group.
Conclusion(s):
Dual trigger of oocyte maturation with GnRHa and low-dose hCG in high responders with peak E2
Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00329-9/fulltext
