Can we skip weekends in GnRH antagonist cycles without compromising the final outcome?

The author discusses the challenges in programming GnRH antagonist cycles.

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Ernesto Bosch, M.D.

Vol 97, Issue 6 , Pages 1299-1300


Gonadotropin-releasing hormone (GnRH) antagonists were introduced into clinical practice more than a decade ago. However, although they offer a number of advantages compared with GnRH agonists, their introduction in daily practice has been slower than initially could be expected. A major drawback for their consolidation has been the limitation for programming cycles, as when the GnRH antagonist protocol gonadotropin administration is started on day 2 or 3 of menses, which is clearly an unpredictable event.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders.