Ovarian response to controlled ovarian hyperstimulation in cancer patients is diminished even before oncological treatment

In a large series, we confirmed that the ovarian response to controlled ovarian hyperstimulation in cancer patients is lower than expected for their age compared with a historical control.


Javier Domingo, M.D., Vicente Guillén, M.D., Yanira Ayllón, M.D., María Martínez, M.D., Elkin Muñoz, M.D., Antonio Pellicer, M.D., Juan A. Garcia-Velasco, M.D.

Volume 97, Issue 4, Pages 930-934



To evaluate the results of controlled ovarian stimulation before chemotherapy for oocyte vitrification to preserve fertility in women diagnosed with cancer and compare them with a historical control group.


A retrospective, multicenter, observational study performed between March 2007 and January 2011.


University-affiliated infertility clinics.


Of 272 patients affected by cancer in our Fertility Preservation Program, 223 women underwent a stimulated cycle for oocyte vitrification according to our protocols before cancer treatment. Their results were compared with a historical control group of 98 patients diagnosed with male factor infertility who were stimulated for a conventional IVF cycle.


Controlled ovarian stimulation and oocyte retrieval.

Main Outcome Measure(s):

Days of stimulation, total dose of gonadotropins, estrogen levels, and number of oocytes retrieved and vitrified.


No differences were found in days of stimulation, but significant differences in E2 levels and the number of retrieved oocytes were measured, especially in the hormone-dependent cancer group.


Patients with hormone-dependent cancer had a weaker response to controlled ovarian stimulation compared with patients with non-hormone-dependent cancer. Whether the oncological disease already affects the ovaries before chemo-/radiotherapy remains to be elucidated.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00122-7/fulltext