David R. Meldrum, M.D.
Volume 97, Issue 3, Pages 536-538
Only 20 years ago we had no understanding of what causes OHSS. The review by Soares (1) chronicles a remarkable story defining granulosa cell (GC) VEGF as the mediator of this syndrome, culminating in treatment with dopamine agonists that block VEGF receptor expression as the cause of increased vascular permeability. I was fortunate to be part of an elegant study by Levin and colleagues (2) using a bioassay for vascular permeability showing that 98% of the bioactivity of follicular fluid in high responders was blocked by an anti-VEGF antibody.
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