March 2012

Preventing severe OHSS has many different facets

Dopamine agonists, decreased FSH and hCG doses, coasting, agonist trigger, paracentesis, metformin, low-dose aspirin, anticoagulation, and possibly FSH co-trigger are measures that prevent or reduce the severity of OHSS.

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Fertility and Sterility
Mar 01, 2012
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Author

David R. Meldrum, M.D.

Volume 97, Issue 3, Pages 536-538

Abstract

Only 20 years ago we had no understanding of what causes OHSS. The review by Soares (1) chronicles a remarkable story defining granulosa cell (GC) VEGF as the mediator of this syndrome, culminating in treatment with dopamine agonists that block VEGF receptor expression as the cause of increased vascular permeability. I was fortunate to be part of an elegant study by Levin and colleagues (2) using a bioassay for vascular permeability showing that 98% of the bioactivity of follicular fluid in high responders was blocked by an anti-VEGF antibody.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)00124-0/fulltext

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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