The relationship between follicle development and progesterone receptor membrane component-1 expression in women undergoing in vitro fertilization

Eighteen percent of women undergoing IVF overexpressed PGRMC1, which was associated with a 30% reduction in follicle development and the number of mature oocytes but not ongoing pregnancy rates.
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Authors

Alyaa Elassar, M.D., Xiufang Liu, Victoria Scranton, Carol A. Wu, Ph.D., John J. Peluso, Ph.D.

Volume 97, Issue 3, Pages 572-578

Abstract

Objective:

To determine the relationship between progesterone receptor membrane component-1 (PGRMC1) expression and the outcome of IVF treatment.

Design:

A prospective study in which PGRMC1 messenger RNA (mRNA) levels, methylation status of the Pgrmc1 promoter, and the presence of point mutations within Pgrmc1 were obtained from granulosa (GC)/luteal cells of women undergoing controlled ovarian hyperstimulation (COH).

Setting:

Fertility center/basic science laboratory.

Patient(s):

Eighty-five patients undergoing IVF treatment and 10 women who were undergoing COH for the purpose of oocyte donation were included in this study.

Intervention(s):

None.

Main Outcome Measure(s):

The PGRMC1 measurements were correlated with clinical outcomes, such as number of follicles, number of retrieved oocytes, and ongoing pregnancy rates (PR).

Result(s):

The PGRMC1 mRNA levels within GC/luteal cells of 18% of IVF patients were >2.25-fold higher than those of oocyte donors. Individuals with elevated PGRMC1 mRNA levels had 30% fewer large follicles and fewer oocytes retrieved. The elevated PGRMC1 mRNA levels were associated with an increase in the methylation of Pgrmc1 promoter.

Conclusion(s):

In patients with elevated PGRMC1 mRNA levels, gonadotropin-induced follicle development is attenuated, although sufficient numbers of follicles develop to allow for ET and subsequent pregnancy.

Read the full text at: http://www.fertstert.org/article/S0015-0282(11)02910-4/fulltext

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