Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers

This study evaluated the association between FSH receptor gene variants and current markers of ovarian reserve. No associations of FSH receptor genotypes with markers of ovarian reserve were detected.

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Lamiya Mohiyiddeen, M.R.C.O.G., William G. Newman, F.R.C.P., Ph.D., Helen McBurney, B.Sc., Betselot Mulugeta, M.Sc., Stephen A. Roberts, Ph.D., Luciano G. Nardo, M.D.

Volume 97, Issue 3, Pages 677-681



To evaluate the association between variants in the FSHR receptor (FSHR) gene and current markers of ovarian reserve (antimüllerian hormone, antral follicle count, FSH).


Prospective observational study.


Tertiary referral center for reproductive medicine.


Women (n = 421) undergoing their first cycle of controlled ovarian stimulation for IVF.


Baseline pelvic ultrasound and blood tests were taken on day 2–3 of the cycle for assessment of baseline hormones and for DNA extraction. Genotypes for FSHR p.Asn680Ser and p.Thr307Ala variants were determined using TaqMan allelic discrimination assays.

Main Outcome Measure(s):

Association of FSHR single nucleotide polymorphisms with markers of ovarian reserve.


There was no evidence of any difference in basal FSH, antimüllerian hormone, or antral follicle count between the patients with different genotypes, with or without an adjustment for age or body mass index.


No associations of FSHR genotypes with markers of ovarian reserve were detected in our cohort.

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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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