Adiponectin and leptin systems in human endometrium during window of implantation

This study provides pertinent insight into the role of both adipokines and more precisely the ratio of leptin to adiponectin in the development of uterine receptivity.

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Authors

Esther Dos Santos, Ph.D., Valérie Serazin, Ph.D., Corinne Morvan, Antoine Torre, Ph.D., Robert Wainer, Ph.D., Philippe de Mazancourt, Ph.D., Marie-Noëlle Dieudonné, Ph.D.

Volume 97, Issue 3, Pages 771-778.e1

Abstract

Objective:

To measure the expression of adiponectin, leptin, and their respective receptors in the human endometria of fertile women compared with women with unexplained recurrent implantation failure (IF) during the window of implantation.

Design:

Controlled, prospective, clinical study.

Setting:

Teaching hospital and university research laboratory.

Patient(s):

Thirty-one endometrial biopsies from women with IF and 19 fertile controls.

Intervention(s):

Human endometrial biopsies.

Main Outcome Measure(s):

Gene and protein expression of endometrial biopsies.

Result(s):

Endometrial leptin expression was significantly lower in the IF group compared with fertile women. In contrast, leptin receptor (Ob-R) expression was higher in endometria of women with IF. Concerning the adiponectin system, adiponectin was expressed to the same extent in both groups. Conversely, the expression of its two receptors, AdipoR1 and AdipoR2, was reduced in endometria of women with IF compared with fertile women.

Conclusion(s):

Although progesterone resistance seems to be a common state of the endometrium in some human reproductive disorders, such as endometriosis or polycystic ovary syndrome, modification in leptin endometrial expression seems to be specific to IF. These results strongly suggest that changes in Ob-R and AdipoR expression profiles [1] should be implicated in the development of uterine receptivity, and [2] may therefore be potential new targets for prediction of IF.

Read the full text at: http://www.fertstert.org/article/S0015-0282(11)02926-8/fulltext

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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