Variants of the WNT7A gene in Chinese patients with müllerian duct abnormalities

One novel synonymous variant and three known single-nucleotide polymorphisms in WNT7A were identified in 191 Chinese patients with m€ullerian duct abnormalities.

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Yujie Dang, M.Sc., Yingying Qin, M.D., Ph.D., Rong Tang, M.D., Ph.D., Yulan Mu, M.D., Ph.D., Guangyu Li, M.Sc., Mingdi Xia, M.Sc., Zi-Jiang Chen, M.D., Ph.D.

Volume 97, Issue 2 , Pages 391-394.e1



To search for WNT7A gene mutations in a cohort of 191 Chinese Han patients with müllerian duct abnormalities (MDAs).


Phenotypic and mutational study.


University hospital.


A total of 191 Chinese Han patients with MDAs and 192 healthy control individuals.


Genomic DNA extracted from blood samples, all coding regions amplified by polymerase chain reaction (PCR) then directly sequenced to screen variants.

Main Outcome Measure(s):

Not applicable.


The sequence analysis revealed one novel synonymous variant and three known single-nucleotide polymorphisms (SNPs).


The results indicate that mutations in the coding sequence of WNT7A are not responsible for müllerian duct abnormalities in the Chinese population.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.