Male fertility: psychiatric considerations

Male infertility may be influenced by psychologic stress and psychotropic agents. Available literature is heterogeneous, and further studies are needed to demonstrate the relationship between stress, antidepressants, and male fertility.

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Elise Hall, M.D. and Vivien K. Burt, M.D., Ph.D.

Volume 97, Issue 2 , Pages 434-439



To examine: 1) current knowledge on normal biologic variation of seminal parameters; 2) how stress and psychological factors affect sperm quality in fertile and infertile males; and 3) how mental illness and psychopharmacologic agents can affect male fertility.


English-language Medline, Embase, and Psycinfo were searched for relevant publications (from 1970 to January 2011) for systematic review.







Main Outcome Measure(s):

Possible effects of stress, mood, and psychotropic medications on male factor fertility.


Male-factor infertility is influenced by myriad factors (obesity, tobacco, etc.). Stress alone may reduce testosterone levels and spermatogenesis. Infertility assessment and treatment can lead to distress and negatively affect sperm samples. Available research has failed to control for potentially confounding variables.


Although some trends have been identified, larger-scale studies that adequately control all confounding variables are needed before conclusions can be made about the relationship between stress, psychotropic agents, and male infertility.

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Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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