Cross-sectional analysis of the effects of age on the hormonal, metabolic, and ultrasonographic features and the prevalence of the different phenotypes of polycystic ovary syndrome

In women with PCOS, hyperandrogenemia appears to diminish during reproductive life whereas insulin resistance persists. This progressive worsening of insulin resistance is primarily driven by the increase in obesity.

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Authors

Dimitrios Panidis, Ph.D., Konstantinos Tziomalos, Ph.D., Djuro Macut, Ph.D., Dimitrios Delkos, Ph.D., George Betsas, Ph.D., Georgios Misichronis, M.D., Ilias Katsikis, Ph.D.

Volume 97, Issue 2 , Pages 494-500

Abstract

Objective:

To assess the effects of age on the hormonal, metabolic, and ultrasonographic features of polycystic ovary syndrome (PCOS).

Design:

Observational study.

Setting:

University department of obstetrics and gynecology.

Patient(s):

Patients with PCOS (n = 1,212) and healthy women (n = 254).

Intervention(s):

None.

Main Outcome Measure(s):

Differences in the hormonal, metabolic, and ultrasonographic features of PCOS between age groups.

Result(s):

A progressive decline in circulating androgens was observed with advancing age. Patients 21–30 years old had lower plasma glucose and insulin levels, lower area under the oral glucose tolerance test curve and lower homeostasis model assessment of insulin resistance index, and higher glucose/insulin and quantitative insulin sensitivity check index than patients 31–39 years old. The prevalence of PCOS phenotypes changed with age. More specifically, the distribution of the phenotypes did not differ substantially between patients ≤20 years old and patients 21–30 years old. However, a decline in the prevalence of phenotype 1 (characterized by anovulation, hyperandrogenemia, and polycystic ovaries) and an increase in the prevalence of phenotype 4 (characterized by anovulation and polycystic ovaries without hyperandrogenemia) were observed in patients 31–39 years old.

Conclusion(s):

In women with PCOS, hyperandrogenemia appears to diminish during reproductive life whereas insulin resistance worsens.

Read the full text at: http://www.fertstert.org/article/S0015-0282(11)02817-2/fulltext

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Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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