Effects of acupuncture and exercise on insulin sensitivity, adipose tissue characteristics, and markers of coagulation and fibrinolysis in women with polycystic ovary syndrome: secondary analyses of a randomized controlled trial

We studied the effect of acupuncture and exercise on hemostatic factors, insulin sensitivity, and adipose tissue characteristics in PCOS. Acupuncture counteracted a possible prothrombotic state in women with PCOS as reflected by decreased plasminogen activator inhibitor activity.

0
0
Like 0 Comment

Authors

Elisabet Stener-Victorin, Ph.D., Fariba Baghaei, Ph.D., M.D., Göran Holm, Ph.D., M.D., Per Olof Janson, Ph.D., M.D., Gunilla Olivecrona, Ph.D., Malin Lönn, Ph.D., Louise Mannerås-Holm, Ph.D.

Volume 97, Issue 2 , Pages 501-508, February 2012

Abstract

Objective:

To investigate the possible effects of low-frequency electroacupuncture (EA) and physical exercise on markers of coagulation and fibrinolysis, insulin sensitivity, and adipose tissue characteristics in women with polycystic ovary syndrome (PCOS).

Design:

Secondary analyses of a prospective, randomized controlled clinical trial.

Setting:

Department of Physiology and Department of Obstetrics and Gynecology, University of Gothenburg.

Patient(s):

Eighty-four women with PCOS were randomized.

Intervention(s):

Women with PCOS were randomized to 16 weeks of low-frequency EA (14 treatments), physical exercise (at least 3 times/wk), or no intervention.

Main Outcome Measure(s):

Anthropometrics, circulating coagulation and fibrinolytic markers, insulin sensitivity (euglycemic hyperinsulinemic clamp), hemodynamics, and adipose tissue morphology/function recorded at baseline, after 16 weeks of intervention, and after a 16-week follow-up.

Result(s):

In the low-frequency EA group, circulating plasminogen activator inhibitor 1 activity decreased by 21.8% after 16 weeks of intervention and by 31.1% at the 16-week follow-up and differed from the physical exercise and the no intervention groups. The EA group had decreases in circulating fibrinogen and tissue plasminogen activator (t-PA), sagittal diameter, and diastolic blood pressure after treatment, and fibrinogen remained lower at the 16-week follow-up. In the physical exercise group, lipoprotein lipase activity increased and diastolic blood pressure decreased after treatment, and both diastolic and systolic blood pressure were lower at follow-up. No other variables were affected.

Conclusion(s):

Low-frequency EA counteracted a possible prothrombotic state in women with PCOS, as reflected by a decrease in plasminogen activator inhibitor 1 activity. Despite within-group improvements, there were no between-group differences in anthropometric, metabolic, or hemodynamic variables after 16 weeks of EA or physical exercise at the dose/intensity studied.

Read the full text at: http://www.fertstert.org/article/S0015-0282(11)02764-6/fulltext

Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.