January 2012

Does PCOS have developmental origins?

The pros and cons of the proposition that PCOS has developmental origins are laid out based on the best available evidence.
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Go to the profile of Fertility and Sterility
Fertility and Sterility
Editorial Office, American Society for Reproductive Medicine
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Author

Stephen Franks, M.D., F.Med.Sci. and Sarah L. Berga, M.D.

Volume 97, Issue 1 , Pages 2-6

Abstract

PRO—The similarity of reproductive and metabolic phenotype between prenatally androgenized sheep, or monkeys, and women with PCOS provides strong supportive evidence for developmental programming being important in the etiology of PCOS. CON—While one would not exclude altogether developmental determinants of PCOS, it is difficult to view PCOS as purely developmental or resulting only from intrauterine exposures or simply an adaptation gone astray.

Read the full text at: http://www.fertstert.org/article/S0015-0282(11)02805-6/fulltext

Go to the profile of Fertility and Sterility
Fertility and Sterility
Editorial Office, American Society for Reproductive Medicine

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