Should all women with PCOS be treated for insulin resistance?

Insulin resistance of variable severity is commonly present in women with PCOS. Arguments and rationale are presented for treating all or only selected women with insulin sensitizing drugs.

0
0
Like 0 Comment

Authors

John C. Marshall, M.D., Ph.D. and Andrea Dunaif, M.D.

Volume 97, Issue 1 , Pages 18-22

Abstract

PRO—A large majority of women with PCOS have insulin resistance, compensatory hyperinsulinemia with consequent reproductive and metabolic abnormalities. Metformin has been shown to be effective therapy and could be used more widely in obese adolescents with hyperandrogenemia, a forerunner of PCOS. CON—The severity of insulin resistance is highly variable in women with PCOS and may not be clinically relevant in milder phenotypes. Treatment should be directed at specific metabolic or reproductive problems and insulin sensitizing drugs are not always the optimum therapy.

Read the full text at: http://www.fertstert.org/article/S0015-0282(11)02812-3/fulltext

Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.