Early pregnancy testosterone after ovarian stimulation and pregnancy outcome

Ovarian stimulation before conception is associated with significant elevations in first-trimester testosterone. Further studies are needed to evaluate the effect of early pregnancy testosterone on outcomes.

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Stephanie L.F. Gustin, M.D., Gourab Mukherjee, Valerie L. Baker, M.D., Lynn M. Westphal, M.D., Amin A. Milki, M.D., Ruth B. Lathi, M.D.

Volume 97, Issue 1 , Pages 23-27.e1



To examine early pregnancy (EP) testosterone (T) after ovarian stimulation and its effect on singleton pregnancy outcomes.


Prospective cohort study.


University-based tertiary care center.


Subfertile women who conceived with or without fertility treatment.


Ovarian stimulation for assisted reproduction, collection of serum total T levels in early pregnancy, and pregnancy follow-up.

Main Outcome Measure(s):

Rate of preterm delivery, low birth weight (LBW) (90th percentile), we did not see an increased risk for preterm delivery, hypertensive disorders of pregnancy, LBW infants, or cesarean delivery (odds ratio ratios 1.43, 0.38, 1.39, and 0.85, respectively).


Elevations in EP T are associated with ovarian stimulation but do not appear to be associated with adverse pregnancy outcome. Further investigation to determine the etiology of increased maternal and neonatal morbidity among subfertile women is warranted.

Read the full text at: http://www.fertstert.org/article/S0015-0282(11)02705-1/fulltext

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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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