Intracytoplasmic sperm injection in partial globozoospermia

Intracytoplasmic sperm injection is the most effective and safe treatment in case of partial globozoospermia, although spontaneous pregnancies do occur in this population.


Anika H.D.M. Dam, M.D., Adriënne J.E. Pijnenburg, M.D., Jan C.M. Hendriks, Ph.D., Hans Westphal, Ph.D., Liliana Ramos, Ph.D., Jan A.M. Kremer, Ph.D.

Volume 97, Issue 1 , Pages 60-66



To compare the outcome of intracytoplasmic sperm injection (ICSI) in patient couples where the male partner has partial globozoospermia with the outcome in a general ICSI population.


Case-control study.


Center for Reproductive Medicine, Radboud University Nijmegen Medical Center, the Netherlands, a tertiary referral center.


Between 1997 and 2005, 42 couples were identified in which the male presented with partial globozoospermia; 27 couples treated with ICSI were matched with 263 control couples from a general ICSI population regarding female age and year of first ICSI cycle.


One ICSI treatment (1–10 ICSI cycles).

Main Outcome Measure(s):

Live birth rate after one ICSI treatment (1–10 ICSI cycles).


In the partial globozoospermia group, the live birth rate was 66.7% compared with 50.0% in the control group. In partial globozoospermia, three out of 21 pregnancies ended in a miscarriage, one major birth defect occurred, and one pregnancy ended in a neonatal death due to sepsis in a premature child, compared with four stillborn in the control group.


ICSI is an effective treatment in couples that failed to conceive spontaneously within 1 year combined with male infertility due to partial globozoospermia. The fertilization rates and the live birth rates in this specific group did not differ from those of the general ICSI population.

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