Bilateral oophorectomy is not associated with increased mortality: the California Teachers Study

Results from previous studies investigating the potential association between surgical menopause due to bilateral oophorectomy and increased mortality are mixed. Bilateral oophorectomy was not associated with increased mortality in the California Teachers Study.


Lei Duan, Ph.D., Xinxin Xu, M.S., Corinna Koebnick, Ph.D., James V. Lacey Jr., Ph.D., Jane Sullivan-Halley, B.S., Claire Templeman, M.D., Sarah F. Marshall, M.A., Susan L. Neuhausen, Ph.D., Giske Ursin, M.D., Ph.D., Leslie Bernstein, Ph.D., Katherine D. Henderson, Ph.D.

Volume 97, Issue 1 , Pages 111-117



To investigate the effect of surgical menopause due to bilateral oophorectomy on mortality, in light of evidence that bilateral oophorectomy among premenopausal women rapidly reduces endogenous hormone levels, thereby modifying risks of cardiovascular disease and breast cancer.


The California Teachers Study (CTS) is a prospective cohort study of 133,479 women initiated in 1995–1996 through a mailed, self-administered questionnaire. Relative risks and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression.




California Teachers Study participants who, at baseline, reported having surgical menopause due to bilateral oophorectomy (n = 9,785), were compared with participants with natural menopause (n = 32,219).



Main Outcome Measure(s):

We investigated whether bilateral oophorectomy was associated with all-cause, cardiovascular, or cancer mortality, overall and by menopausal hormone therapy use status.


Among participants aged


Surgical menopause due to bilateral oophorectomy vs. natural menopause does not increase all-cause, cardiovascular, or cancer mortality.

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