Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters

Lowering of androgens and insulin during pregnancy in mothers with polycystic ovary syndrome reduces anti-Mullerian hormone levels in their daughters, which might reflect a decrease in their follicular mass.


Nicolás Crisosto, Ph.D., Bárbara Echiburú, Ph.D., Manuel Maliqueo, Ph.D., Virginia Pérez, M.D., Amanda Ladrón de Guevara, M.D., Jessica Preisler, M.D., Fernando Sánchez, M.D., Teresa Sir-Petermann, Ph.D.

Volume 97, Issue 1 , Pages 218-224



To evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSd+M), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd−M) and daughters of women who belong to a healthy comparison group (HCd).


Descriptive and analytic study.


Unit of endocrinology and reproductive medicine.


Fifteen PCOSd+M, 23 PCOSd−M, and 35 HCd were studied at 2–3 months of age.


A GnRH analogue test was performed with determinations of gonadotropins, sex steroids, SHBG, and anti-Müllerian hormone (AMH).

Main Outcome Measure(s):

Differences in AMH levels between PCOSd+M, PCOSd−M and HCd.


AMH and peak E2 concentrations were significantly higher in PCOSd−M compared with HCd, whereas PCOSd+M exhibited AMH concentrations and peak E2 levels similar to those observed in HCd.


The improvement of the altered endocrine-metabolic environment of PCOS mothers reduces AMH levels in their daughters, which might reflect a decrease in their follicular mass.

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