Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters

Lowering of androgens and insulin during pregnancy in mothers with polycystic ovary syndrome reduces anti-Mullerian hormone levels in their daughters, which might reflect a decrease in their follicular mass.

Upvote 1 Comment


Nicolás Crisosto, Ph.D., Bárbara Echiburú, Ph.D., Manuel Maliqueo, Ph.D., Virginia Pérez, M.D., Amanda Ladrón de Guevara, M.D., Jessica Preisler, M.D., Fernando Sánchez, M.D., Teresa Sir-Petermann, Ph.D.

Volume 97, Issue 1 , Pages 218-224



To evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSd+M), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd−M) and daughters of women who belong to a healthy comparison group (HCd).


Descriptive and analytic study.


Unit of endocrinology and reproductive medicine.


Fifteen PCOSd+M, 23 PCOSd−M, and 35 HCd were studied at 2–3 months of age.


A GnRH analogue test was performed with determinations of gonadotropins, sex steroids, SHBG, and anti-Müllerian hormone (AMH).

Main Outcome Measure(s):

Differences in AMH levels between PCOSd+M, PCOSd−M and HCd.


AMH and peak E2 concentrations were significantly higher in PCOSd−M compared with HCd, whereas PCOSd+M exhibited AMH concentrations and peak E2 levels similar to those observed in HCd.


The improvement of the altered endocrine-metabolic environment of PCOS mothers reduces AMH levels in their daughters, which might reflect a decrease in their follicular mass.

Read the full text at:

Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.