Antimüllerian hormone and F2-isoprostanes in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

In a population-based sample, higher F2-isoprostanes, an indicator of systemic oxidative stress, are associated with lower antimullerian hormone, particularly in younger women.
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VOLUME 114, ISSUE 3, P646-652

Authors:

Catherine Kim, M.D., M.P.H., James C. Slaughter, Ph.D., James G. Terry, M.S., David R. Jacobs Jr., Ph.D., Nisha Parikh, M.D., Duke Appiah, Ph.D., Benjamin Leader, M.D., Ph.D., Molly B. Moravek, M.D., Melissa F. Wellons, M.D.

Abstract:

Objective

To examine whether F2-isoprostanes, a marker of systematic oxidative stress, are associated with antimüllerian hormone (AMH), an indicator of ovarian reserve, in a population-based cohort of women of black and white ethnicities.

Design

Cross-sectional analysis.

Setting

Not applicable.

Patients

The CARDIA Women’s Study, a population-based cohort. Black (n = 398) and white (n = 432) late reproductive−aged women (mean age 40 ± 3.6 years) without histories of gynecologic surgery.

Main Outcome Measures

Log-transformed serum AMH concentrations.

Results

Linear regression models evaluated whether plasma F2-isoprostanes were associated with log-transformed AMH after adjustment for age, race, smoking, body mass index, and oral contraceptive pill use. Higher levels of F2-isoprostanes were associated with lower AMH levels (β −0.048 per standard deviation, 95% confidence interval −0.087, −0.01). The observed associations were stronger at younger ages (P=.04 for interaction between levels of age and F2-isoprostanes). Indicators of other steps in the oxidative stress pathway (superoxide dismutase, paraoxonase activity, oxidized low-density lipoprotein cholesterol, and carotenoids) were not associated with AMH, although lower phospholipase A2 activity (β 0.036 per standard deviation, 95% confidence interval 0.001, 0.071) was associated with lower AMH across all ages.

Conclusion

In a population-based cohort, higher levels of F2-isoprostanes were associated with lower ovarian reserve, particularly at younger ages.

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