Reproductive outcomes after IVF treatment in a cohort of Danish women transplanted with cryopreserved ovarian tissue

A majority of women undergoing ovarian tissue trans- plantation reveal a poor ovarian response during IVF treatment, and the reproductive outcomes depict this fact; however, outcomes after frozen embryo transfer appear to be superior to fresh embryo transfer.

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VOLUME 114, ISSUE 2, P379-387

Authors:

Ina Marie Dueholm Hjorth, M.D., Stine Gry Kristensen, Ph.D., Margit Dueholm, PhD, M.D., Peter Humaidan, D.M.Sc.

Abstract:

Objective

To evaluate ovarian stimulation regimens and reproductive outcomes in a cohort of women undergoing ovarian tissue cryopreservation (OTC) and ovarian tissue transplantation (OTT).

Design

Retrospective cohort study.

Setting

University hospital and fertility clinics.

Patients

Twenty-eight women undergoing OTT and in vitro fertilization (IVF) from 2012 to 2017.

Intervention

OTC, OTT, and IVF.

Main Outcome Measures

Ovarian stimulation and IVF outcomes.

Results

In total, 99 cycles were performed in 28 patients. In 19 patients responding to stimulation, a median of 3.0 cycles per patient (range: 1–14 cycles) was performed, and 2.0 mature oocytes were retrieved per cycle. The empty follicle rate was 35.9%. Eleven women achieved 15 pregnancies, of which 60% were lost during the first or second trimester, resulting in 5 of 28 women having ≥1 live births, and seven healthy children being born. In breast cancer patients (mean age at OTC: 33.0 years), the pregnancy rates (PR) and live birth rates (LBR) were 35.0% and 5.0% per embryo transfer, respectively. Patients aged ≥34.5 years at OTC all had breast cancer and did not achieve any pregnancies. For all other diagnoses (mean age at OTC: 26.6 years), PR and LBR were 50.0% and 37.5% per embryo transfer, respectively. Collectively, 39% of patients conceived at least once, and 17.9% delivered. Frozen-thawed embryo transfer (FET) resulted in more pregnancies than did fresh embryo transfer.

Conclusion

Our results suggest that women of advanced maternal age undergoing OTC and IVF have a poor ovarian reserve, resulting in a poor reproductive outcome. Interestingly, FET appeared to be superior to fresh transfer.

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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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