January 2020: The efficacy of PGT-A: an RCT

Journal Club Global

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Santiago Munne, Ph.D., along with coauthors Alan Handyside, Ph.D., and Tony Gordon, Ph.D. are joined by experts in the field including Richard Paulson, M.D., and Glenn Schattman, M.D. to discuss the recent Fertility and Sterility paper, "Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial."

  • Did the use of PGT-A increase live birth rate in this trial? Who benefitted, and who did not?
  • How is this data from an RCT similar or different from other data (RCT and cohorts)?
  • What factors may have contributed to different finding based on age?
  • Do we need more RCTs on this question? And how should they be designed? 
  • What are the advantages and pitfalls of analyses such as ITT, per protocol and post hoc? Does the outcome differ in each analysis?

This Journal Club Global is hosted by Erica Johnstone, M.D., M.H.S, with the REI program at the University of Utah, and by Fertility and Sterility's Video and New Media Editor, Kurt Barnhart, M.D., M.S.C.E.


Register to view the event here: https://www.workcast.com/register?cpak=1377636988799423

View the archive for all Journal Club Global videos here: https://www.fertstert.org/content/video.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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