Interpretation of clinical trial results: a committee opinion
This document provides guidance, background, and tips on how to recognize quality trials and focuses on evaluating the validity, importance, and relevance of clinical trial results.
Volume 113, Issue 2, Pages 295–304
Practice Committee of the American Society for Reproductive Medicine
Evidence from clinical trials is fundamental to ethical medical practice. Along with patient preferences, circumstances, and clinical experience, evidence is central to effective clinical decision-making. Applying evidence to clinical questions requires ﬁltering in the form of three questions. First, do the trial results reflect true effects of intervention, rather than artifactual ones (validity)? Second, do the results suggest that the intervention is clinically useful (importance)? Third, could the results apply to individual patients encountered in daily practice (relevance)? This document provides background and tips on how to recognize trials of quality and focus on evaluating the validity, importance, and relevance of clinical trial results (Table 1).