Post-orgasmic illness syndrome: history and current perspectives
Post-orgasmic illness syndrome is a rare and debilitating condition causing somatic and psychological symptoms leading to severe distress in affected men and their partners
Volume 113, Issue 1, Pages 13–15
Mark R. Paulos, M.D., Gabriella J. Avelliino, M.D.
Post-orgasmic illness syndrome is a rare disorder causing a debilitating cluster of flu-like and allergic type symptoms that occur within seconds, minutes or hours after ejaculation. Symptoms occur after intercourse, masturbation or spontaneous ejaculation and last from 2 to 7 days. The condition is chronic and follows a primary pattern occurring in adolescence and a secondary acquired pattern with onset later in life. The true incidence is unknown as the condition is likely under-reported and under-diagnosed. The pattern of symptoms suggests an allergic or auto-immune etiology; however, the exact pathophysiology is unknown and there is no effective treatment. Men suffering from post-orgasmic illness syndrome describe emotional trauma and significant impairment of their quality of life.