Association between prepregnancy subnormal body weight and obstetrical outcomes after autologous in vitro fertilization cycles: systematic review and meta-analysis

Compared with women of normal weight, those who were underweight before pregnancy had a lower clinical pregnancy rate and live birth rate after assisted reproductive treatment.

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Volume 113, Issue 2, Pages 344–353.e2

Authors:

Yi-quan Xiong, Ph.D., Yan-mei Liu, MM, Ya-na Qi, MM, Chun-rong Liu, MM, Jing Wang, BM, Ling Li, Ph.D., Kang Zou, BM, Jing Tan, Ph.D., Xin Sun, Ph.D.

Abstract:

Objective

To study the association between prepregnancy subnormal body weight and obstetrical outcomes after autologous in vitro fertilization (IVF) cycles.

Design

Systematic review and meta-analysis.

Setting

Not applicable.

Patient(s)

Women with prepregnancy subnormal body weight (body mass index <18.5 kg/m2) and normal body weight (body mass index 18.5–25 kg/m2) after assisted reproductive treatment.

Interventions(s)

None.

Main Outcome Measure(s)

Clinical pregnancy rate (CPR), live birth rate (LBR), and miscarriage rate. CPR and LBR were calculated at per-woman and per-cycle levels.

Result(s)

A total of 38 cohort studies with low risk of bias were included. Meta-analyses showed that, compared with normal-weight women, those underweight before pregnancy had a lower CPR at per-woman and per-cycle levels. Compared with normal weight, underweight before pregnancy had little impact on LBR at both per-woman and per-cycle levels, nor on miscarriage rate.

Conclusion(s)

Compared with women of normal weight, women who were underweight before pregnancy had modest association with a lower CPR, but underweight did not seem to affect LBR or miscarriage after IVF.


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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