Effect of body mass index on pregnancy outcomes with the freeze-all strategy in women with polycystic ovarian syndrome

An elevated body mass index has a statistically inverse association with the live birth rate in women with polycystic ovary syndrome with the freeze- all strategy.

Volume 112, Issue 6, Pages 1172–1179


Meiting Qiu, M.D., Yu Tao, M.D., Ph.D., Yanping Kuang, M.D., Ph.D., Yun Wang, M.D., Ph.D.



To investigate the effects of body mass index (BMI) on assisted reproductive outcomes with the freeze-all strategy for patients with polycystic ovary syndrome (PCOS).


Retrospective cohort study.


Tertiary care academic medical center.


A total of 3,079 women with PCOS across different BMIs at our institution from January 2015 to May 2017 were stratified into cohorts.



Main Outcome Measure(s)

Implantation rate, clinical pregnancy rate, early miscarriage rate, and live birth rate.


The live birth rate was most favorable in underweight (BMI < 18.5 kg/m2) and normal weight cohorts (18.5 ≤ BMI < 25 kg/m2) and progressively decreased as BMI increased. Moreover, the obese cohort (BMI ≥ 30 kg/m2) of patients with PCOS who had frozen ET cycles had a relatively high early miscarriage rate.


The live birth rates are highest in underweight and normal weight patients with PCOS undergoing IVF with the freeze-all strategy. Furthermore, there is a progressive and statistically significant decrease in the live birth rate and an increase in the miscarriage rate in obese patients with PCOS.

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