An induced pluripotent stem cell–derived granulosa cell model revealed hyperactive CREB signaling in polycystic ovary syndrome subjects

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An induced pluripotent stem cell–derived granulosa cell model revealed hyperactive CREB signaling in polycystic ovary syndrome subjects
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An induced pluripotent stem cell–derived granulosa cell model revealed hyperactive CREB signaling in polycystic ovary syndrome subjects

Polycystic ovary syndrome (PCOS) is one of the most common endocrine metabolic disorders, affecting 5%–15% of women, and is characterized by ovulatory dysfunction, polycystic ovarian morphology, hyperandrogenism, obesity, and insulin resistance (1). Several large genome-wide association studies have…

Volume 112, Issue 3, Pages 480–481

Authors:

Tianyanxin Sun, Ph.D., Margareta D. Pisarska, M.D.

Abstract:

Reflections on "Hyperactive CREB signaling pathway involved in the pathogenesis of polycystic ovarian syndrome revealed by patient-specific induced pluripotent stem cell modeling" by Huang et al.


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